Collagen Usage in joints

What is collagen?
Collagen is a protein, with characteristic elasticity.

How effects in the joints?
Mainly helps the elasticity of cartilage. Cartilage has a smooth and glossy surface that helps to correct movement of the joint, with a very low coefficient of friction between the moving bones.

When cartilage is damaged?
Can occur either after injury, or by impaired vascularization of the bone or as a result of aging with the precursor stage change in composition of synovial fluid..

What is synovial fluid?
The synovial fluid that lubricates articular cartilage, increases its ability to work as a mechanism that absorbs mechanical stress. Midlife synovial fluid begins to lose its normal analog form and becomes 'dilute'. This results in the cartilage to fatigue and start showing 'cracks.' Important role in this process plays a substance called interleukin 1 (IL-1).

How collagen acts in these cases?

Practical help in improving pain and regeneration of cartilage and connective tissue surrounding the joint.

How is delivered?
Either oral or by injection into the joint.

How is the treatment designed?
This depends on the type of injury, the age, body weight, the hinge, the particular disease that may exist (eg diabetes, rheumatoid arthritis, etc.), and if there is disturbance in the mechanical axis of the leg (eg. varusknee)

When such treatment is contra-indicated?
In cases with end-stage arthritis and especially with deformities of mechanical axis of the leg, the treatment with collagen has no place.

The injectabletreatment is better;
Yes, if a single joint is impaired and particular the cartilage.

Drugs on the market are divided into better and worse. Is this true?
The practical differences between the prescription formulations is the molecular weight (MW). Some have MW = 1800-2000 kDaltons, while others have MW = 2400-3600 kDaltons. Also, differ both in manufacturing technology, and the viscosity. None of them has the molecular weight of the human healthy synovial fluid, that is 4000-7000 kDaltons. Consider that in osteoarthritis due to aging, the MW of synovial fluid is only 1000 kDaltons.

Suggestion. Those with the highest MW are better?
So, if we take into account the effect on the healing of cartilage, yes but, on the other side the others with lower MW have better analgesic effect on pain receptors present in the synovium. Another factor that should not be ignored is the repeatability of injections. Otherwise the patient complies with one injection at 12 months and another different to 10 injections at the same time.

Are these injections suitable in rheumatoid arthritis?
Because RA is a systematic disease, such treatments have no effect. Instead, here are suitable subcutaneous injections with anti-TNFa agents. The TNFa (Tumor Necrosis Factor) tumor necrosis factor, is responsible for this disease pathogenetic. So the pharmaceutical inhibition of this factor is the goal therapeutically.

Injections of cortisone (steroids) have an effect on the joints?
As anti-inflammatory therapy have effevtiveness, of course only temporary, to treat inflammation of the synovium, however, they have an adverse effect on the articular cartilage, and increase the likelihood of local infection.